Ethanol → HCID 56623337, compound

HRID 1903320Notes

Reaction equation

HRID 1903320 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:13])[CH2:11][CH3:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(OCC)(OCC)[O:15][CH2:16][CH3:17].C(=O)(O)[O-].[CH2:28](O)[CH3:29]>C1(C)C=CC(S(O)(=O)=O)=CC=1.C(N(CC)CC)C>[CH2:28]([O:13][C:10]([O:15][CH2:16][CH3:17])([C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1)[CH2:11][CH3:12])[CH3:29]

Participants

7

Reactant 4

HCID 702EthanolHCID 769Bicarbonate IonHCID 31214Ethyl orthoformateHCID 37734351-(4-isopropylphenyl)propan-1-one

Product 1

HCID 56623337HCID 56623337, compoundYield 75.1%

Reagents, catalysts & solvents 2

HCID 6101p-Toluenesulfonic acidCatalystHCID 8471TriethylamineCatalyst

Procedure

48 ml of absolute ethanol and 1 g of p-toluenesulphonic acid are placed in a round flask which is fitted with a stirrer, thermometer, condenser and dropping funnel. Now, there are added dropwise within 30 minutes while stirring 181.5 g of p-isopropyl-propiophenone and subsequently within 1 hour 152.5 g of triethyl orthoformate. The temperature is held at 30° C. by external cooling. The mixture is subsequently stirred for a further 22 hours at 20°-25° C. The mixture is then adjusted to pH 8 with 5 g of triethylamine and thereupon poured into 50 ml of 5% bicarbonate solution and 80 g of ice. The aqueous phase is separated and extracted with ether. The combined organic phases are washed with 5% bicarbonate solution and, after the addition of 0.3 g of sodium carbonate, the solvent is removed by evaporation under a vacuum and the residue is distilled over a 15 cm column. There are obtained 193.6 g of p-isopropyl-propiophenone diethyl ketal (yield: 75.1% of theory). B.p.=66° C./0.05 mmHg; nD20 =1,4778; d420 =0,9305.

Workup

  1. customwhich is fitted with a stirrer
  2. customthermometer, condenser and dropping
  3. additionNow, there are added dropwise within 30 minutes
  4. customis held at 30° C. by external cooling
  5. customThe aqueous phase is separated
  6. extractionextracted with ether
  7. washThe combined organic phases are washed with 5% bicarbonate solution
  8. additionafter the addition of 0.3 g of sodium carbonate
  9. customthe solvent is removed by evaporation under a vacuum
  10. distillationthe residue is distilled over a 15 cm column

Sources & evidence

ORD record
ord-2939c393025b4ab1908220065e41fc95
Source dataset
uspto-grants-1984_03
Patent number
US04435585

Reaction notes

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