Triethylamine → HCID 13246740, compound

HRID 1903641Notes

Reaction equation

HRID 1903641 reaction equation
Cl.[NH2:2][C:3]1[CH2:4][S:5][CH2:6][C:7]=1[C:8]([O:10][CH3:11])=[O:9].C(N(CC)CC)C.[CH:19]1([N:25]=[C:26]=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C>[CH:19]1([NH:25][C:26]([NH:2][C:3]2[CH2:4][S:5][CH2:6][C:7]=2[C:8]([O:10][CH3:11])=[O:9])=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 18502Cyclohexyl isocyanateHCID 20466347HCID 20466347, compound

Product 1

HCID 13246740HCID 13246740, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
25 °C

Procedure

9.3 parts by weight of 3-amino-4-methoxycarbonyl-1,5-dihydrothiophene hydrochloride, 6.0 parts by weight of triethylamine, 7.4 parts by weight of cyclohexyl isocyanate and 30 parts by weight of acetonitrile were combined, and the mixture was stirred for 3 hours at 25° C. and then evaporated down. The residue was washed with water and recrystallized from toluene. 4.5 parts by weight of N-cyclohexyl-N'-(3-methoxycarbonyl-2,5-dihydrothien-4-yl)-urea of melting point 153°-154° C. were obtained.

Workup

  1. customevaporated down
  2. washThe residue was washed with water
  3. customrecrystallized from toluene

Sources & evidence

ORD record
ord-7e2f58aac2fc4cb08b3ad2f349293b54
Source dataset
uspto-grants-1984_03
Patent number
US04437878

Reaction notes

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