Hydrochloric Acid → H-(D)Ala-Gly-OBzl.hydrochloride

HRID 1903866Notes

Reaction equation

HRID 1903866 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])=[O:5])[CH3:3].[ClH:25].CCOCC>O1CCOCC1>[NH2:1][C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])=[O:5])[CH3:3].[ClH:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15567200Boc-(D)Ala-Gly-OBzl

Product 1

HCID 131712174H-(D)Ala-Gly-OBzl.hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.4 g of Boc-(D)Ala-Gly-OBzl are dissolved in 50 ml of dioxane containing HCl and left to stand for one hour. The volume of the solution is reduced under vacuum and an excess of ether added. The precipitated salt is filtered off, dried and used as such for the coupling reaction.

Workup

  1. waitleft
  2. filtrationThe precipitated salt is filtered off
  3. customdried
  4. customsuch for the coupling reaction

Sources & evidence

ORD record
ord-9f20d9343e204aba90facb8abb9f7130
Source dataset
uspto-grants-1984_03
Patent number
US04438103

Reaction notes

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