Hydrochloric Acid → HCID 13290543, compound

HRID 1903876Notes

Reaction equation

HRID 1903876 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:25]=[CH:24][C:6]2[N:7]([C:10]3[CH:23]=[CH:22][C:13]([O:14][CH:15]([CH3:21])[C:16]([O:18]CC)=[O:17])=[CH:12][CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1.[OH-].[Na+].Cl>C(O)C>[F:27][C:2]([F:1])([F:26])[C:3]1[CH:25]=[CH:24][C:6]2[N:7]([C:10]3[CH:23]=[CH:22][C:13]([O:14][CH:15]([CH3:21])[C:16]([OH:18])=[O:17])=[CH:12][CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13290538HCID 13290538, compound

Product 1

HCID 13290543HCID 13290543, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.7 g of 1, 0.39 g of sodium hydroxide and 50 ml of ethanol was refluxed for two hours, then it was cooled to room temperature, acidified with hydrochloric acid and extracted with ether. Concentration of the ether extract gave 2, as a white solid, m.p.: 181°-182° C.

Workup

  1. temperaturewas refluxed for two hours
  2. extractionextracted with ether
  3. extractionConcentration of the ether extract
  4. customgave 2

Sources & evidence

ORD record
ord-95eb83fcdf71499eb43802964162dd18
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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