HCID 15589123, compound → HCID 20456650, compound

HRID 1903880Notes

Reaction equation

HRID 1903880 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][C:15]1[CH:29]=[CH:28][C:18]([O:19][CH:20]([CH2:25][O:26][CH3:27])[C:21]([O:23][CH3:24])=[O:22])=[CH:17][CH:16]=1)([O-])=O.[H][H]>O1CCCC1>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][C:15]1[CH:16]=[CH:17][C:18]([O:19][CH:20]([CH2:25][O:26][CH3:27])[C:21]([O:23][CH3:24])=[O:22])=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 15589123HCID 15589123, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20456650HCID 20456650, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 17 g of 10B in 100 ml of tetrahydrofuran was treated with hydrogen (40 psi hydrogen pressure, Parr-shaker, 10% palladium-on-charcoal catalyst) to give methyl 2-(4-(2-amino-4-(trifluoromethyl)phenylamino)phenoxy)-3-methoxypropionate (10C), as an oil.

Sources & evidence

ORD record
ord-79274dbdd76249ea925fe3d9382effc9
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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