HRID1904027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

结构：CCCCCCCCCCCCCCCC(=O)Nc1cc(O)c2ccccc2c1OCOCCOC

HCID131713445

未命名化合物

结构：Cc1c(N=Nc2ccc(COS(=O)(=O)c3ccccc3)cc2)c(O)n(C)c(=O)c1C#N

HCID178430934

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCC(=O)Nc1cc(OCc2ccc(N=Nc3c(C)c(C#N)c(=O)n(C)c3O)cc2)c2ccccc2c1OCOCCOC

HCID178443074

未命名化合物

收率 70.6%

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

5 g of Compound [1-f] was dissolved in 30 ml of dried diglime and to the solution was added 0.48 g of a 50% oily sodium hydride. Then, 4.4 g of Compound [2-b] was added and the mixture was stirred at 80° C. for 1.5 hours. By subjecting the same treatment as described in Step [1-i], 5.5 g of Compound [2-c] was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9ac3f14169fa4a38b615efed18c6f3d2
来源数据集: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04439513
来源说明: uspto-grants-1984_03

反应 SMILES

[C:1]([NH:18][C:19]1[CH:20]=[C:21]([OH:36])[C:22]2[C:27]([C:28]=1[O:29][CH2:30][O:31][CH2:32][CH2:33][O:34][CH3:35])=[CH:26][CH:25]=[CH:24][CH:23]=2)(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[H-].[Na+].[C:39]([C:41]1[C:42](=[O:69])[N:43]([CH3:68])[C:44]([OH:67])=[C:45]([N:48]=[N:49][C:50]2[CH:55]=[CH:54][C:53]([CH2:56]OS(C3C=CC=CC=3)(=O)=O)=[CH:52][CH:51]=2)[C:46]=1[CH3:47])#[N:40]>>[C:39]([C:41]1[C:42](=[O:69])[N:43]([CH3:68])[C:44]([OH:67])=[C:45]([N:48]=[N:49][C:50]2[CH:55]=[CH:54][C:53]([CH2:56][O:36][C:21]3[C:22]4[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:28]([O:29][CH2:30][O:31][CH2:32][CH2:33][O:34][CH3:35])=[C:19]([NH:18][C:1](=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH:20]=3)=[CH:52][CH:51]=2)[C:46]=1[CH3:47])#[N:40]