3-Amino-1-propanol → 3-(4-Diethylcarbamoyl-2-pyridyloxy)propylamine

HRID 1904085Notes

Reaction equation

HRID 1904085 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8](=[O:14])[N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])[CH:5]=[CH:4][N:3]=1.[NH2:15][CH2:16][CH2:17][CH2:18][OH:19].[H-].[Na+]>>[CH2:10]([N:9]([CH2:12][CH3:13])[C:8]([C:6]1[CH:5]=[CH:4][N:3]=[C:2]([O:19][CH2:18][CH2:17][CH2:16][NH2:15])[CH:7]=1)=[O:14])[CH3:11]

Participants

4

Reactant 3

HCID 90863-Amino-1-propanolHCID 24758Sodium hydrideHCID 19010922HCID 19010922, compound

Product 1

HCID 202390653-(4-Diethylcarbamoyl-2-pyridyloxy)propylamine

Procedure

2-Chloro-4-diethylcarbamoylpyridine is reacted with 3-aminopropanol and sodium hydride to give 3-(4-diethylcarbamoyl-2-pyridyloxy)propylamine, which is reduced with lithium aluminium hydride in tetrahydrofuran to give 3-(4-diethylaminomethyl-2-pyridyloxy)propylamine;

Sources & evidence

ORD record
ord-e5cf31ba4a134a588dec88e487c8a8ff
Source dataset
uspto-grants-1984_03
Patent number
US04439609

Reaction notes

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