Azepane → 1-(azepan-1-yl)octan-1-one

HRID 1904181Notes

Reaction equation

HRID 1904181 reaction equation
[C:1](Cl)(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[NH:11]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>>[C:1]([N:11]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 8119AzepaneHCID 8124Octanoyl chloride

Product 1

HCID 2468241-(azepan-1-yl)octan-1-oneYield 68%

Procedure

In a manner similar to that described in Example 1, octanoyl chloride (16.26 g, 0.1M) was treated with hexahydro-1H-azepine (9.92 g, 0.1M). Work up and distillation of the residue gave 15.3 g (68%) of product, b.p. 122/0.8 mm.

Workup

  1. distillationdistillation of the residue

Sources & evidence

ORD record
ord-58ba5aae3d1442228bd6a60aa643af18
Source dataset
uspto-grants-1989_06
Patent number
US04837026

Reaction notes

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