Hydrochloric Acid → HCID 178454468, compound

HRID 1904189Notes

Reaction equation

HRID 1904189 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([SH:13])=[N:11][N:10]=[N:9]2)=[CH:4][CH:3]=1.[C:14](Cl)(=[O:18])[C:15]([CH3:17])=[CH2:16].[OH-].[Na+].Cl>C(#N)C.N1C=CC=CC=1>[C:14]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([SH:13])=[N:11][N:10]=[N:9]2)=[CH:4][CH:3]=1)(=[O:18])[C:15]([CH3:17])=[CH2:16]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 13528Methacryloyl chloride2×HCID 14798Sodium HydroxideHCID 178507704HCID 178507704, compound

Product 1

HCID 178454468HCID 178454468, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6342AcetonitrileSolvent

Procedure

Thirty grams of 1-(p-aminophenyl)-1,2,3,4-tetrazole-5-thiol was dissolved in 300 ml of acetonitrile and 20 ml of pyridine, and 16 ml of methacrylic acid chloride was added dropwise to the resulting solution with agitation. After the addition of the methacrylic acid chloride, the mixture was agitated for 1 hour at room temperature. Thereafter, a 10% aqueous solution of sodium hydroxide was added and the mixture was agitated for a white. The mixture was rendered weakly acidic with dilute hydrochloric acid and the end compound was obtained as a white crystal in an amount of 29.4 g (yield, 72%).

Workup

  1. stirringthe mixture was agitated for a white
  2. customthe end compound was obtained as a white crystal in an amount of 29.4 g (yield, 72%)

Sources & evidence

ORD record
ord-50de426854d84321817a4f906abd7c7b
Source dataset
uspto-grants-1989_06
Patent number
US04837141

Reaction notes

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