Potassium Carbonate → HCID 14671800, compound

HRID 1904237Notes

Reaction equation

HRID 1904237 reaction equation
[Br:1][C:2]1[C:3](=[O:13])[N:4]([C:9]([CH3:12])([CH3:11])[CH3:10])[N:5]=[CH:6][C:7]=1[OH:8].[CH2:14]([O:17][CH2:18][CH2:19][CH2:20][O:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Br)=[CH:24][CH:23]=1)[CH2:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[C:3](=[O:13])[N:4]([C:9]([CH3:10])([CH3:12])[CH3:11])[N:5]=[CH:6][C:7]=1[O:8][CH2:26][C:25]1[CH:24]=[CH:23][C:22]([O:21][CH2:20][CH2:19][CH2:18][O:17][CH2:14][CH2:15][CH3:16])=[CH:29][CH:28]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 14671799HCID 14671799, compoundHCID 54718038HCID 54718038, compound

Product 1

HCID 14671800HCID 14671800, compoundYield 41.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 20 ml of N,N-dimethylformamide were dissolved 1.7 g of 4-bromo-2-t-butyl-5-hydroxy-3(2H)-pyridazinone and 2.0 g of 4-(3-propoxypropoxy)-benzyl bromide, and 1.3 g of anhydrous potassium carbonate was added thereto. The resulting mixture was heated under stirring on an oil bath at 80° to 90° C. for 3 hours. Then, procedures similar to those in Preparation Example 2 were carried out to obtain 1.3 g of the aimed compound as an oil.

Workup

  1. additionwas added
  2. temperatureThe resulting mixture was heated
  3. customThen, procedures similar to those in Preparation Example 2

Sources & evidence

ORD record
ord-d555bc10be4e4231a5e3ef82f5d1f4b8
Source dataset
uspto-grants-1989_06
Patent number
US04837217

Reaction notes

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