反应详情

A solution of sodium hydroxide (2.70 g, 0.674 mole) in water (110 ml) was added to 1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxylic acid methyl ester prepared as above (6.39 g, 0.0225 mole) and the resulting solution was stirred for 2 hours. The solution was cooled in ice, acidified to pH 2 with 3N hydrochloric acid, and the product was filtered and dried. The product was recrystallized from ethanol-water and dried to give 1-(3,5-difluorobenzyl)-2-mercapto-imidazole-5-carboxylic acid, m.p.: 240°-241° C. (5.66 g, 93%).

1. temperatureThe solution was cooled in ice
2. filtrationthe product was filtered
3. customdried
4. customThe product was recrystallized from ethanol-water
5. customdried