反应详情

A mixture of 200 mg of 5-(4-chlorophenyl)-δ-valerolactone, 0.5 g of aniline, 20 mg of p-toluenesulfonic acid and 10 ml of xylene was refluxed for 6 hours. After removal of solvent, the residue was extracted with ethyl acetate. The extract was washed with diluted hydrochloric acid and a saturated aqueous sodium chloride solution and dried. After removal of the solvent, the residue was purified, by silica gel thin layer chromatography (solvent; chloroform:methanol=10:1) to give 60 mg of 6-(4-chlorophenyl)-1-phenyl-2-piperidone.

1. temperaturewas refluxed for 6 hours
2. customAfter removal of solvent
3. extractionthe residue was extracted with ethyl acetate
4. washThe extract was washed with diluted hydrochloric acid
5. dry with materiala saturated aqueous sodium chloride solution and dried
6. customAfter removal of the solvent
7. customthe residue was purified, by silica gel thin layer chromatography (solvent; chloroform:methanol=10:1)