反应详情

温度

100 °C

A mixture of 130 mg of 1-(4-acetylaminophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane-2,4-dione and 1 ml of approx. 18% hydrochloric acid is stirred for about 4 hours at 100° C. The reaction mixture is adjusted at 0° C. to pH 9-10 with saturated aqueous sodium bicarbonate solution and extracted twice with ethyl acetate. The organic phases are washed until neutral with a small amount of water and a dilute solution of sodium chloride, dried over magnesium sulfate, filtered and concentrated. Recrystallisation from ethyl acetate/petroleum ether affords the title compound which is identical with the title compound of Example 3(a).

1. extractionextracted twice with ethyl acetate
2. washThe organic phases are washed until neutral with a small amount of water
3. dry with materiala dilute solution of sodium chloride, dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customRecrystallisation from ethyl acetate/petroleum ether