Trifluoroacetic acid → HCID 86743158, compound

HRID 1904942Notes

Reaction equation

HRID 1904942 reaction equation
C([C:8]([S:10][C:11]1[C:16]2=[N:17][CH:18]=[C:19]([C:22]([O:24]CC3C=CC(OC)=CC=3)=[O:23])[C:20](=[O:21])[N:15]2[CH:14]=[CH:13][CH:12]=1)=[O:9])C1C=CC=CC=1.[C:34]1(OC)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.FC(F)(F)[C:44](O)=[O:45]>C(Cl)Cl>[CH2:44]([O:45][C:8]([S:10][C:11]1[C:16]2=[N:17][CH:18]=[C:19]([C:22]([OH:24])=[O:23])[C:20](=[O:21])[N:15]2[CH:14]=[CH:13][CH:12]=1)=[O:9])[C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 86743159HCID 86743159, compound

Product 1

HCID 86743158HCID 86743158, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 0.872 g of 9-(benzylcarbonyl)thio-3-(4-methoxybenzyloxycarbonyl)-4H-pyrido[1,2-a]pyrimidin-4-one Ie-79, 2.5 g of anisole and 10 ml of dry methylene chloride is cooled with ice water, mixed with 5 ml of trifluoroacetic acid and stirred under cooling with ice water for 3 hours. The reaction mixture is concentrated to dryness in vacuo, and the residue is recrystallized from ethyl acetate to give the titled compound Ie-80.

Workup

  1. concentrationThe reaction mixture is concentrated to dryness in vacuo
  2. customthe residue is recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-b162e0084c504ee3b92e6a16fc253a27
Source dataset
uspto-grants-1989_06
Patent number
US04840953

Reaction notes

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