Trifluoroacetic acid → HCID 14476551, compound

HRID 1904943Notes

Reaction equation

HRID 1904943 reaction equation
[CH3:1][N:2]([CH3:29])[C:3]([S:5][C:6]1[C:11]2=[N:12][CH:13]=[C:14]([C:17]([O:19]CC3C=CC(OC)=CC=3)=[O:18])[C:15](=[O:16])[N:10]2[CH:9]=[CH:8][CH:7]=1)=[O:4].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>C(Cl)Cl>[C:17]([C:14]1[C:15](=[O:16])[N:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:5][C:3](=[O:4])[N:2]([CH3:1])[CH3:29])[C:11]2=[N:12][CH:13]=1)([OH:19])=[O:18]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 14306467HCID 14306467, compound

Product 1

HCID 14476551HCID 14476551, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 0.508 g of 9-(dimethylcarbamoyl)thio-3-(4-methoxybenzyloxycarbonyl)-4H-pyrido[1,2-a]pyrimidin-4-one Ib-82, 2,5 g of anisole and 5 ml of dry methylene chloride is cooled with ice water, mixed with 5 ml of trifluoroacetic acid and stirred under cooling with ice water for 3 hours. The reaction mixture is concentrated in vacuo to dryness, and the residue is washed with ether to give 0.32 g of crude product, which is recrystallized from 95% ethanol to give the titled compound Ib-81.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo to dryness
  2. washthe residue is washed with ether
  3. customto give 0.32 g of crude product, which
  4. customis recrystallized from 95% ethanol

Sources & evidence

ORD record
ord-0940ceb21f5142c3a921ed6a84350dcb
Source dataset
uspto-grants-1989_06
Patent number
US04840953

Reaction notes

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