Hydrazine hydrate (1:1) → HCID 13576831, compound

HRID 1905030Notes

Reaction equation

HRID 1905030 reaction equation
C([NH:4][CH:5]1[CH:19]2[CH:8]([CH2:9][C:10]3[C:18]4[C:17]2=[CH:16][CH:15]=[CH:14][C:13]=4[N:12](S(C2C=CC=CC=2)(=O)=O)[CH:11]=3)[N:7]([CH3:29])[CH2:6]1)(=O)C.O.NN>>[NH2:4][CH:5]1[CH:19]2[CH:8]([CH2:9][C:10]3[C:18]4[C:17]2=[CH:16][CH:15]=[CH:14][C:13]=4[NH:12][CH:11]=3)[N:7]([CH3:29])[CH2:6]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13576805HCID 13576805, compound

Product 1

HCID 13576831HCID 13576831, compound

Procedure

To the N-benzenesulphonyl-9-acetamide (Example 10) (0.15 g) was added with stirring hydrazine hydrate (4 cm3) and the mixture heated to reflux under anhydrous conditions. After 24 hours all solid had dissolved to give a clear orange solution. All solvents were removed under high vacuum (<30° C.) to give after trituration with water (10 cm3) and acetone (2×10 cm3) an orange solid.

Workup

  1. temperaturethe mixture heated
  2. temperatureto reflux under anhydrous conditions
  3. dissolutionAfter 24 hours all solid had dissolved
  4. customto give a clear orange solution
  5. customAll solvents were removed under high vacuum (<30° C.)
  6. customto give after trituration with water (10 cm3) and acetone (2×10 cm3) an orange solid

Sources & evidence

ORD record
ord-c0ecdd28159a42bfa2e13ad8beeb4604
Source dataset
uspto-grants-1989_06
Patent number
US04841056

Reaction notes

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