Hydrochloric Acid → methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

HRID 1905333Notes

Reaction equation

HRID 1905333 reaction equation
[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([OH:7])=[O:6].[CH3:13]O>>[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([O:7][CH3:13])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 12879199(2RS,3S)-3-amino-2-hydroxy-5-methylhexanoic acid

Product 1

HCID 13746619methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

Procedure

Hydrogen chloride was passed into a solution of 110 mg of (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoic acid in 10 ml of methanol with stirring, and the mixture was stirring overnight, and the mixture was evaporated to dryness under reduced pressure to obtain 150 mg of methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride as a white powder. [IR (KBr): νco 1740 cm-1 ].

Workup

  1. stirringthe mixture was stirring overnight
  2. customthe mixture was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-9a387301a494401db47c6b1cae668875
Source dataset
uspto-grants-1989_06
Patent number
US04841067

Reaction notes

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