Trimethyl phosphite → HCID 10397128, compound

HRID 1905372Notes

Reaction equation

[CH3:1][C@H:2]([OH:7])[CH2:3][C@@H:4]([OH:6])[CH3:5].[CH3:8][O:9][P:10](OC)OC>>[CH3:8][O:9][P:10]1[O:7][C@@H:2]([CH3:1])[CH2:3][C@H:4]([CH3:5])[O:6]1

Participants

Reactant 2

HCID 8472Trimethyl phosphite

HCID 69502002,4-Pentanediol, (+)-

Product 1

HCID 10397128HCID 10397128, compound

Conditions

Temperature: 100 °C

Procedure

10 g of (+)-(2S,4S)pentane-2,4-diol and 13.6 g of trimethylphosphite were mixed, and heated at 100° C. on an oil bath. After completion of distilling methanol off, the residue is distilled under reduced pressure to obtain colorless transparent 2-methoxy-(4S,6S)-4,6-dimethyl-1,3,2-dioxaphosphorinane. bp: 70°-72° C./15 mmHg.

Workup

distillationAfter completion of distilling methanol off, the residue is distilled under reduced pressure

Sources & evidence

ORD record: ord-82d308ee3d8b49a1be651a2daef599f0
Source dataset: uspto-grants-1989_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04843076

Reaction notes

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