Hydrochloric Acid → HCID 15631324, compound

HRID 1905390Notes

Reaction equation

HRID 1905390 reaction equation
[C:1]([C:9]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][NH:14]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:20]>CCOCC>[ClH:20].[C:1]([C:9]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][NH:14]2)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15631323HCID 15631323, compound

Product 1

HCID 15631324HCID 15631324, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 215.1 mg (0.85 mmol) of 5-benzoyl-1,2,3,4-tetrahydro-8-quinolinol in 5 ml of ether was treated with 3 ml of hydrogen chloride saturated ether. The fluffy white precipitate was filtered off and recrystallized from dichloromethane-methanol-hexane to obtain 130.8 mg of a white solid, dried at 56° C./0.1 mm of Hg; melting point 237°-239° C., dec.

Workup

  1. filtrationThe fluffy white precipitate was filtered off
  2. customrecrystallized from dichloromethane-methanol-hexane

Sources & evidence

ORD record
ord-e80b30ee310644ab839029d1d424306e
Source dataset
uspto-grants-1989_06
Patent number
US04843082

Reaction notes

Loading…