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HRID1905429

反应详情

EQUATION

反应方程式

HRID 1905429 的结构方程式

REACTANTS

反应物

2
结构：C1CNCCN1
HCID4837

Piperazine

C4H10N2

结构：CCOC(=O)c1c2n(c3cc(F)c(F)cc3c1=O)C(C)S2
HCID10380740

Ethyl 6,7-difluoro-1-methyl-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

C14H11F2NO3S

PRODUCTS

生成物

1
结构：CCOC(=O)c1c2n(c3cc(N4CCNCC4)c(F)cc3c1=O)C(C)S2
HCID10249018

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

C18H20FN3O3S

收率 49.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate (5.0 g) was suspended in 150 ml of N,N-dimethylformamide and the suspension was stirred with 4.6 g of piperazine at room temperature for 48 hours. N,N-Dimethylformamide was evaporated in vacuo and to the residue was added ice water to collect the crystals by filtration. Purification by a column chromatography (silica gel/chloroform-methanol (1:1)) gave 3.0 g of desired compound, m.p. 224° C. (decompn.).

WORKUP

后处理

  1. customN,N-Dimethylformamide was evaporated in vacuo and to the residue
  2. additionwas added ice water
  3. customto collect the crystals
  4. filtrationby filtration
  5. customPurification by a column chromatography (silica gel/chloroform-methanol (1:1))