Potassium Carbonate → HCID 14303262, compound

HRID 1905432Notes

Reaction equation

HRID 1905432 reaction equation
Cl[CH:2]1[CH2:7][CH:6]([CH2:8][CH:9]([CH3:11])[CH3:10])[O:5][C:3]1=[O:4].C(=O)([O-])[O-:13].[K+].[K+]>Cl>[OH:13][CH:2]1[CH2:7][CH:6]([CH2:8][CH:9]([CH3:11])[CH3:10])[O:5][C:3]1=[O:4]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 14303261HCID 14303261, compound

Product 1

HCID 14303262HCID 14303262, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In a 50 ml flask with a cooling column, 1.77 g (10 mmole) of α-chloro-γ-isobutyl-γ-butyrolactone and 12 ml of 2N aqueous potassium carbonate were kept at 80 C. for 40 hours under stirring. The reaction mixture was cooled to room temperature and poured into 10 ml of 12N hydrochloric acid. The reaction product was extracted with ether and the ether extract was dried with anhydrous sodium sulfate. After removal of ether, distillation of the residue under reduced pressure gave α-hydroxy-γ-isobutyl-γ-butyrolactone. (yield 99%).

Workup

  1. extractionThe reaction product was extracted with ether
  2. extractionthe ether extract
  3. dry with materialwas dried with anhydrous sodium sulfate
  4. customAfter removal of ether, distillation of the residue under reduced pressure

Sources & evidence

ORD record
ord-22baa828ad35409d95eb28cda1d86828
Source dataset
uspto-grants-1989_06
Patent number
US04843093

Reaction notes

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