反应详情

7.2 g (30 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanol are dissolved in 30 ml of dimethyl-formamide, and after the addition of 2.2 g (16 mMol) of potassium carbonate, 4.26 g (30 mMol) of methyliodide are added dropwise. When the slightly exothermic reaction has ended, the mixture is concentrated by evaporation, mixed with water and extracted with chloroform. The concentrated extracts are chromatographed on silica gel to purify them (eluant; methylene chloride/methanol=20/1).

1. additionare added dropwise
2. customWhen the slightly exothermic reaction
3. concentrationthe mixture is concentrated by evaporation
4. additionmixed with water
5. extractionextracted with chloroform
6. customThe concentrated extracts are chromatographed on silica gel
7. customto purify them (eluant; methylene chloride/methanol=20/1)