Acetic Acid → HCID 13578906, compound

HRID 1905449Notes

Reaction equation

HRID 1905449 reaction equation
C(O)(=[O:3])C.FC(F)(F)C(O)=O.[F:12][C:13]1[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[C:14]=1[C:15]([NH:17][C:18]([NH:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([C:29]([F:34])([F:33])[CH:30]([F:32])[F:31])=[O:28])=[CH:23][C:22]=1[F:35])=[O:19])=[O:16].OO>O>[F:12][C:13]1[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[C:14]=1[C:15]([NH:17][C:18]([NH:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([C:29]([F:33])([F:34])[CH:30]([F:31])[F:32])(=[O:3])=[O:28])=[CH:23][C:22]=1[F:35])=[O:19])=[O:16]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 6422Trifluoroacetic acidHCID 13578905HCID 13578905, compound

Product 1

HCID 13578906HCID 13578906, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

In a mixed solution consisting of 5 ml of acetic acid and 10 ml of trifluoroacetic acid was dissolved under heating 0.6 g of N-(2-fluoro-6-chlorobenzoyl)-N'-[2-fluoro-4-(1,1,2,2-tetrafluoroethylsulfinyl)phenyl]urea, and 1.5 ml of 30% hydrogen peroxide aqueous solution was added to the solution, followed by heating at 90° C. for 2 hours. The reaction mixture was diluted with water, and the crystals which separated out were recovered by filtration, and washed with water and ethanol successively to give 0.6 g of N-(2-fluoro-6-chlorobenzoyl)-N'-[2-fluoro-4-(1,1,2,2-tetrafluoroethylsulfonyl)phenyl]urea (Compound No. 6), m.p. of 176°-177° C.

Workup

  1. dissolutionwas dissolved
  2. additionwas added to the solution
  3. customthe crystals which separated out
  4. filtrationwere recovered by filtration
  5. washwashed with water and ethanol successively

Sources & evidence

ORD record
ord-3ff8ccaeed8e44d2902d714a512177b6
Source dataset
uspto-grants-1989_06
Patent number
US04843100

Reaction notes

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