反应详情

To a solution of 3,4-dihydro-6-(3,4-dihydroxyphenyl)-1,3-dimethyl-4-(2,4,6-trimethylphenylimino)-2(1H)pyrimidinone (2.0 g) in N,N-dimethylformamide (20 ml) were added sodium hydride (60% in Nujol, 0.22 g) and methyl iodide (0.37 ml), and the mixture was stirred at ambient temperature for 2 hours. Then the reaction mixture was poured into water (200 ml), and extracted with ethyl acetate. The organic extract was washed with brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel eluting with chloroform to give 3,4-dihydro-1,3-dimethyl-6-(4-hydroxy-3-methoxyphenyl)-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone (0.66 g).

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. washwas washed with brine
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customThe residue was chromatographed on silica gel eluting with chloroform