Hydrochloric Acid → HCID 178432540, compound

HRID 1905939Notes

Reaction equation

HRID 1905939 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[C:9]([Br:17])[CH:8]=2)[N:6]=1.Cl.[OH-].[Na+]>O>[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]([Br:17])[CH:8]=2)[N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178474093HCID 178474093, compound

Product 1

HCID 178432540HCID 178432540, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-methyl-4-(3-bromo-4-acetamido-phenyl)-1H-imidazole (15 g), concentrated hydrochloric acid (10 ml) and water (30 ml) was refluxed for 45 minutes. The resulting solution was cooled to room temperature and was made alkaline with 10% sodium hydroxide. The base was filtered off, washed with water and dried to give 10 g of the title compound.

Workup

  1. temperaturewas refluxed for 45 minutes
  2. filtrationThe base was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-7cf150e128504844842734ec82ff2680
Source dataset
uspto-grants-1987_03
Patent number
US04649150

Reaction notes

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