Sulfuric Acid → HCID 178469706, compound

HRID 1906038Notes

Reaction equation

HRID 1906038 reaction equation
C(=O)([O-])[O-].[K+].[K+].[H][H].[CH3:9][CH:10]([OH:25])[CH:11]([OH:24])[C:12]1[N:17]=[C:16]2[C:18]([N:20]=[C:21]([NH2:23])[NH:22][C:15]2=[N:14][CH:13]=1)=[O:19].S(=O)(=O)(O)O>[Pt]>[CH3:9][CH:10]([OH:25])[CH:11]([OH:24])[CH:12]1[NH:17][C:16]2[C:18]([N:20]=[C:21]([NH2:23])[NH:22][C:15]=2[NH:14][CH2:13]1)=[O:19]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 11430Potassium Carbonate2×HCID 178418361HCID 178418361, compound2×HCID 178469705HCID 178469705, compound

Product 1

HCID 178469706HCID 178469706, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

Ten milligrams of platinum black was dispersed into 10 ml of 10% aqueous solution of potassium carbonate, and then the catalyst was activated with hydrogen gas. Then, 10 ml of 10% aqueous solution of potassium carbonate containing 50 mg of biopterin was added to the above dispersion. After the catalytic reduction was conducted by agitating the resulting mixture for 20 hours under normal temperature and normal pressure in a hydrogen atmosphere, the reaction mixture was adjusted to pH 1 by adding 20 ml of 10% aqueous solution of sulfuric acid. The catalyst was filtered off from the reaction mixture to give a solution of tetrahydrobiopterin having a (6R)/(6S) ratio of 90/10 as measured by HPLC.

Workup

  1. filtrationThe catalyst was filtered off from the reaction mixture

Sources & evidence

ORD record
ord-77f64c4f26374275b5d262970cc1d061
Source dataset
uspto-grants-1987_03
Patent number
US04649197

Reaction notes

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