Hydrochloric Acid → HCID 20213849, compound

HRID 1906062Notes

Reaction equation

HRID 1906062 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[Cl:21])=[CH:6][C:5]=1[NH:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])([O-:3])=[O:2].Cl.[C:31](Cl)(=[O:33])[CH3:32]>>[C:31]([N:22]([C:5]1[CH:6]=[C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:13][C:12]=2[Cl:21])[CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])[CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])(=[O:33])[CH3:32]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 19858589HCID 19858589, compound2×

Product 1

HCID 20213849HCID 20213849, compound

Procedure

10 g of methyl N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]-4-amino-n-butyrate (compound 2) are refluxed in 30 ml of acetyl chloride until the evolution of hydrogen chloride is complete. Excess acetyl chloride is removed in vacuo, affording the title compound in quantitative yield. nD21 =1.5437.

Workup

  1. customExcess acetyl chloride is removed in vacuo

Sources & evidence

ORD record
ord-94ae5161d1bf4c19a222b377c8fb7699
Source dataset
uspto-grants-1987_03
Patent number
US04649212

Reaction notes

Loading…