Lithium Hydroxide → HCID 20212908, compound

HRID 1906216Notes

Reaction equation

HRID 1906216 reaction equation
C[O:2][C:3](=[O:36])[CH2:4][O:5][C:6]1[CH:35]=[CH:34][C:9]2[C:10](=[O:33])[CH2:11][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([C:26](=[O:28])[CH3:27])=[C:22]([OH:29])[C:21]=3[CH2:30][CH2:31][CH3:32])([CH3:14])[O:13][C:8]=2[CH:7]=1.[OH-].[Li+]>O1CCCC1.O>[C:26]([C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][C:12]2([CH3:14])[CH2:11][C:10](=[O:33])[C:9]3[CH:34]=[CH:35][C:6]([O:5][CH2:4][C:3]([OH:36])=[O:2])=[CH:7][C:8]=3[O:13]2)=[C:21]([CH2:30][CH2:31][CH3:32])[C:22]=1[OH:29])(=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 54379057HCID 54379057, compound

Product 1

HCID 20212908HCID 20212908, compoundYield 97.9%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

Using the procedure of Example 24, the chromanone ester from Example 39 was saponified with lithium hydroxide in tetrahydrofuran-water giving rac.-[[2-[4-(4-acetyl-3-hydroxy-2-propylphenoxy)butyl]-3,4-dihydro-2-methyl-4-oxo-2H-1-benzopyran-7-yl]oxy]acetic acid in 97.9% yield, as a viscous, amber oil.

Sources & evidence

ORD record
ord-485342cb10cc454d914a3e4b27e1272d
Source dataset
uspto-grants-1987_03
Patent number
US04650812

Reaction notes

Loading…