Hydrochloric Acid → HCID 13386126, compound

HRID 1906731Notes

Reaction equation

HRID 1906731 reaction equation
C([O:3][C:4]([CH2:6][O:7][C:8]1[C:9]([CH:19]([CH3:21])[CH3:20])=[N:10][N:11]2[CH:16]=[C:15]([CH2:17][CH3:18])[CH:14]=[CH:13][C:12]=12)=[O:5])C.Cl>[OH-].[Na+]>[C:4]([CH2:6][O:7][C:8]1[C:9]([CH:19]([CH3:20])[CH3:21])=[N:10][N:11]2[CH:16]=[C:15]([CH2:17][CH3:18])[CH:14]=[CH:13][C:12]=12)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13386142HCID 13386142, compound

Product 1

HCID 13386126HCID 13386126, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
90 °C

Procedure

To 500 mg of the compound prepared in Example 6 were added 20 ml of 2N sodium hydroxide solution, and the mixture was heated for 1 hour in a water bath at 90° C. The reaction mixture was neutrallized with 2N hydrochloric acid to be acidic condition (pH 3) under cooling in an ice bath. The resulting precipitates were collected by filtration and recrystallized from a mixture of benzene and hexane to give 374 mg (83.9%) of the desired product as colorless powder, mp 118°-119° C.

Workup

  1. temperatureunder cooling in an ice bath
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. customrecrystallized from a mixture of benzene and hexane

Sources & evidence

ORD record
ord-e11e178b2d9e4656949cb2571fdd307c
Source dataset
uspto-grants-1987_03
Patent number
US04654349

Reaction notes

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