3'-Aminoacetophenone → HCID 898301, compound

HRID 1906841Notes

Reaction equation

HRID 1906841 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.C(N(C(C)C)CC)(C)C.[CH:20]1([C:24](Cl)=[O:25])[CH2:23][CH2:22][CH2:21]1>ClCCl>[C:8]([C:4]1[CH:3]=[C:2]([NH:1][C:24]([CH:20]2[CH2:23][CH2:22][CH2:21]2)=[O:25])[CH:7]=[CH:6][CH:5]=1)(=[O:10])[CH3:9]

Participants

5

Reactant 3

HCID 74173'-AminoacetophenoneHCID 78705Cyclobutanecarbonyl chlorideHCID 81531Diisopropylethylamine

Product 1

HCID 898301HCID 898301, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

An 11.4 g portion of m-aminoacetophenone, 10.9 g of diisopropylethylamine, 10.0 g of cyclobutanecarboxylic acid chloride and 200 ml of dichloromethane were reacted as described in Example 1, giving 14.68 g of N-(3-acetylphenyl)cyclobutanecarboxamide.

Sources & evidence

ORD record
ord-b2c806a863084c318dacd8fdd1be75b6
Source dataset
uspto-grants-1987_03
Patent number
US04654347

Reaction notes

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