3'-Aminoacetophenone → HCID 1640925, compound

HRID 1906845Notes

Reaction equation

HRID 1906845 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.C(N(C(C)C)CC)(C)C.Cl[C:21]([O:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:22]>ClCCl>[C:8]([C:4]1[CH:3]=[C:2]([NH:1][C:21](=[O:22])[O:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:7]=[CH:6][CH:5]=1)(=[O:10])[CH3:9]

Participants

5

Reactant 3

HCID 74173'-AminoacetophenoneHCID 61140Butyl chloroformateHCID 81531Diisopropylethylamine

Product 1

HCID 1640925HCID 1640925, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 27.03 g of m-aminoacetophenone, 25.85 g of diisopropylethylamine, 27.32 g of n-butyl chloroformate and 300 ml of dichloromethane was reacted as described in Example 1, giving 42.10 g of (3-acetylphenyl)carbamic acid, butyl ester, mp 59°-60° C.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-4664e600bde543f389f970903dc58eb2
Source dataset
uspto-grants-1987_03
Patent number
US04654347

Reaction notes

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