Cysteamine Hydrochloride → HCID 13800183, compound

HRID 1906940Notes

Reaction equation

HRID 1906940 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][SH:5].[H-].[Na+].[CH2:8]([N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:16]1Cl)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CN(C)C=O.O>[CH2:8]([N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:16]1[S:5][CH2:4][CH2:3][NH2:2])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

6

Reactant 3

HCID 9082Cysteamine HydrochlorideHCID 24758Sodium hydrideHCID 14112481HCID 14112481, compound

Product 1

HCID 13800183HCID 13800183, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

2-Aminoethanethiol hydrochloride (0.419 g, 3.12 mmol) was added to a stirred suspension of sodium hydride (0.314 g, 50% in mineral oil, 6.56 mmol) in anhydrous dimethylformamide (30 ml) and after 1 hour, 1-benzyl-2-chloro-3-methylsulfonylindole (1.0 g, 3.29 mmol) was added. One half hour thereafter the solution was diluted with water, the product extracted with ether, the extract dried over sodium sulfate and evaporated in vacuo. The product was obtained as a solid, M.P.-95°-96°.

Workup

  1. extractionthe product extracted with ether
  2. dry with materialthe extract dried over sodium sulfate
  3. customevaporated in vacuo
  4. customThe product was obtained as a solid, M.P.-95°-96°

Sources & evidence

ORD record
ord-2223fa2b6f854f139c98423afb599650
Source dataset
uspto-grants-1987_03
Patent number
US04654360

Reaction notes

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