1-Methylpiperazine → HCID 178492052, compound

HRID 1907239Notes

Reaction equation

HRID 1907239 reaction equation
C1(N2C(=O)C3=CNC4[CH:14]=[C:15]([N:19]5[CH2:24]CN[CH2:21][CH2:20]5)C=CC=4C3=N2)C=CC=CC=1.[NH2:27][C:28]1[CH:29]=[CH:30][C:31]2[C:32]3[C:33]([C:38](=[O:49])[N:39]([C:41]4[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][CH:42]=4)[N:40]=3)=[CH:34][NH:35][C:36]=2[CH:37]=1.CN1CCNCC1>>[CH3:48][O:47][C:44]1[CH:45]=[CH:46][C:41]([N:39]2[C:38](=[O:49])[C:33]3=[CH:34][NH:35][C:36]4[CH:37]=[C:28]([N:27]5[CH2:21][CH2:20][N:19]([CH3:24])[CH2:15][CH2:14]5)[CH:29]=[CH:30][C:31]=4[C:32]3=[N:40]2)=[CH:42][CH:43]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 178492053HCID 178492053, compoundHCID 178515224HCID 178515224, compound

Product 1

HCID 178492052HCID 178492052, compound

Procedure

The title compound was prepared following the procedure for 14a using 13c and 1-methylpiperazine. 1H-NMR (CD3OD) δ (ppm): 2.32 (3H, s), 2.67 (4H, brm), 3.40 (4H, brm), 3.85 (3H, s), 6.88 (2H, m), 7.02 (1H, d, J=2.47 Hz), 7.31 (1H, dd, J=9.06, 2.20 Hz), 7.66 (2H, m), 8.16 (1H, d, J=9.06 Hz), 8.52 (1H, s). m/z 390.4 (MH+).

Sources & evidence

ORD record
ord-ef7e02b579564571a291e1947a0b045e
Source dataset
uspto-grants-2013_12
Patent number
US08598159B2

Reaction notes

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