1-(2-Pyridyl)piperazine → HCID 69245226, compound

HRID 1907596Notes

Reaction equation

HRID 1907596 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15](=[O:19])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2.[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15]([N:29]2[CH2:30][CH2:31][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)[CH2:27][CH2:28]2)=[O:19])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 69243736ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate

Product 1

HCID 69245226HCID 69245226, compoundYield 88%

Procedure

Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(2-pyridyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 88%). 1H NMR (300 MHz, CDCl3): δ 2.49 (s, 3H), 3.61-3.71 (m, 8H), 4.12 (s, 3H), 6.66 (d, J=8 Hz, 2H), 7.07-7.74 (m, 5H), 8.20 (dd, J=5.4, 1.8 Hz, 1H).

Sources & evidence

ORD record
ord-144bc944ed554064965fc98fd452c1f2
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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