Trifluoroacetic acid → HCID 59737551, compound

HRID 1907704Notes

Reaction equation

HRID 1907704 reaction equation
[CH3:1][N:2]([CH3:21])[C@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:20]=[CH:19][C:11]([C:12]([O:14]C(C)(C)C)=[O:13])=[CH:10][CH:9]=2)[CH2:4]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][N:2]([CH3:21])[C@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:20]=[CH:19][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)[CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59737216HCID 59737216, compound

Product 1

HCID 59737551HCID 59737551, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl ester 98 (0.595 g, 2.05 mmol) in 1:1 trifluoroacetic acid:DCM (6 mL) was stirred at room temperature for 3 h then concentrated to give title compound 99 (used as is in the next reaction). LRMS: 234.14 (calc) 235.1 (obs)

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-38e586edc2be426e8b568c3bac6ecd38
Source dataset
uspto-grants-2013_12
Patent number
US08598168B2

Reaction notes

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