Methanol → HCID 69100806, compound

HRID 1907722Notes

Reaction equation

HRID 1907722 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][C:6]1[S:10][C:9]([C:11]2[CH:12]=[CH:13][C:14]([N+:28]([O-])=O)=[C:15]([NH:17][C:18](=[O:27])[C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)[CH:16]=2)=[CH:8][CH:7]=1.CO.C(N(CC)CC)C>C(Cl)Cl>[NH2:28][C:14]1[CH:13]=[CH:12][C:11]([C:9]2[S:10][C:6]([CH2:5][NH:4][CH2:3][CH2:2][OH:1])=[CH:7][CH:8]=2)=[CH:16][C:15]=1[NH:17][C:18](=[O:27])[C:19]1[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 8471TriethylamineHCID 59737532HCID 59737532, compound

Product 1

HCID 69100806HCID 69100806, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the same procedure as described in Example 14, step 4 (scheme 14) but substituting compound 146 for compound 192, the title compound 193 was obtained after column chromatography (46% yield, eluent: 50% MeOH in DCM with 1% triethylamine).

Sources & evidence

ORD record
ord-288223e7287d48408c77e89d0fb7be07
Source dataset
uspto-grants-2013_12
Patent number
US08598168B2

Reaction notes

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