Ethyl Acetate → HCID 59737296, compound

HRID 1907723Notes

Reaction equation

HRID 1907723 reaction equation
[Si]([O:18][CH2:19][C:20]1[S:24][C:23]([C:25]2[CH:30]=[CH:29][C:28]([NH:31][C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[C:27]([NH:39][C:40](=[O:53])[C:41]3[CH:46]=[CH:45][C:44]([C:47]4[CH:48]=[N:49][CH:50]=[CH:51][CH:52]=4)=[CH:43][CH:42]=3)[CH:26]=2)=[CH:22][CH:21]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.CCOC(C)=O>C(Cl)Cl>[OH:18][CH2:19][C:20]1[S:24][C:23]([C:25]2[CH:30]=[CH:29][C:28]([NH:31][C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[C:27]([NH:39][C:40](=[O:53])[C:41]3[CH:42]=[CH:43][C:44]([C:47]4[CH:48]=[N:49][CH:50]=[CH:51][CH:52]=4)=[CH:45][CH:46]=3)[CH:26]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 59737457HCID 59737457, compound

Product 1

HCID 59737296HCID 59737296, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the same procedure as described in Example 20, step 5 (scheme 20) but substituting compound 189 for compound 198, title compound 199 was obtained in 90% yield [after column chromatography (eluent: 25% AcOEt in DCM)].

Sources & evidence

ORD record
ord-0f70abb40f92493fa893d7473f3311c3
Source dataset
uspto-grants-2013_12
Patent number
US08598168B2

Reaction notes

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