Triethylamine → HCID 59737349, compound

HRID 1907751Notes

Reaction equation

HRID 1907751 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11](=[O:25])[NH:12][C:13]2[CH:18]=[C:17]([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)[CH:16]=[CH:15][C:14]=2[NH2:24])[CH:6]=1)(=O)C.C(N(CC)CC)C>CO>[NH2:24][C:14]1[CH:15]=[CH:16][C:17]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[CH:18][C:13]=1[NH:12][C:11](=[O:25])[C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([OH:4])[CH:6]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 59737478HCID 59737478, compound

Product 1

HCID 59737349HCID 59737349, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of acetate 296 (349 mg, 0.99 mmol) in dry MeOH (6 mL) was treated with triethyl amine (1.5 mL) and stirred at room temperature for 19 h, concentrated under reduced pressure and triturated with diethyl ether to provide the title compound 297 (282.5 mg, 92% yield).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customtriturated with diethyl ether

Sources & evidence

ORD record
ord-6a5ce18d6ab84384ab55bd46ea2aa3a4
Source dataset
uspto-grants-2013_12
Patent number
US08598168B2

Reaction notes

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