Methyl 4-amino-5-nitropyridine-2-carboxylate → Methyl 4,5-diaminopyridine-2-carboxylate

HRID 1907885Notes

Reaction equation

HRID 1907885 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([N+:11]([O-])=O)=[CH:6][N:5]=1>C1COCC1.[Pd]>[NH2:10][C:8]1[C:7]([NH2:11])=[CH:6][N:5]=[C:4]([C:3]([O:2][CH3:1])=[O:14])[CH:9]=1

Participants

4

Reactant 1

HCID 46835478Methyl 4-amino-5-nitropyridine-2-carboxylate

Product 1

HCID 66997018Methyl 4,5-diaminopyridine-2-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 83d by hydrogenation of methyl-4-amino-5-nitropicolinate using palladium/charcoal 10% in THF.

Sources & evidence

ORD record
ord-27962eb3ad594589bff808d237e2923a
Source dataset
uspto-grants-2013_12
Patent number
US08598190B2

Reaction notes

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