反应详情

温度

15 °C

A solution consisting of 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone (2.00 g, 8.16 mmol) and DMF (7 mL) was cooled to 15° C. and treated portion-wise with sodium azide (583 mg, 8.98 mmol). Once addition was complete, the reaction mixture was stirred for 3 h with gradual warming to rt. The reaction mixture was then diluted with EtOAc (20 mL) and washed with water (25 mL×2), NaHCO3 (satd., 25 mL×2), and brine. The combined organic phases were dried (Na2SO4) and concentrated to dryness to yield the title compound (1.69 g, 100%).

1. additionOnce addition
2. temperaturewith gradual warming to rt
3. washwashed with water (25 mL×2), NaHCO3 (satd., 25 mL×2), and brine
4. dry with materialThe combined organic phases were dried (Na2SO4)
5. concentrationconcentrated to dryness