HCID 67026976, compound → HCID 21804750, compound

HRID 1908734Notes

Reaction equation

HRID 1908734 reaction equation
C[O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([CH2:11][OH:12])[CH:5]=1>Cl>[OH:12][CH2:11][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([CH3:10])[N:7]=1)[C:3]([OH:13])=[O:2]

Participants

3

Reactant 1

HCID 67026976HCID 67026976, compound

Product 1

HCID 21804750HCID 21804750, compoundYield 104%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 2-hydroxymethyl-6-methyl-isonicotinic acid methyl ester (500 mg, 2.76 mmol) in 32% aq. HCl (10 mL) is stirred at 60° C. for 5 h before it is evaporated and dried under HV to give the title compound as a yellow solid (480 mg); LC-MS: tR=0.16 min, [M+1]+=168.04.

Workup

  1. customis evaporated
  2. customdried under HV

Sources & evidence

ORD record
ord-efa4af1f4bcb479b86a0080e02482fc1
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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