6-Isopropylamino-5-methyl-nicotinic acid isopropyl ester → 6-(Isopropylamino)-5-methylnicotinic acid

HRID 1908787Notes

Reaction equation

HRID 1908787 reaction equation
C([O:4][C:5](=[O:17])[C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([NH:13][CH:14]([CH3:16])[CH3:15])=[N:8][CH:7]=1)(C)C>Cl>[CH:14]([NH:13][C:9]1[C:10]([CH3:12])=[CH:11][C:6]([C:5]([OH:17])=[O:4])=[CH:7][N:8]=1)([CH3:16])[CH3:15]

Participants

3

Reactant 1

HCID 670269016-Isopropylamino-5-methyl-nicotinic acid isopropyl ester

Product 1

HCID 584180846-(Isopropylamino)-5-methylnicotinic acidYield 118.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 6-isopropylamino-5-methyl-nicotinic acid isopropyl ester (137 mg, 0.58 mmol) in 25% aq. HCl (5 mL) is stirred at 65° C. for 24 h before it is concentrated and dried to give the title compound (133 mg) as a yellow solid; LC-MS: tR=0.57 min, [M+1]+=195.54.

Workup

  1. concentrationis concentrated
  2. customdried

Sources & evidence

ORD record
ord-920dc38bc9f043c7a445c051de7d7f6c
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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