反应详情

Diethyl malonate (30 gm) was added to 1-(4-cyanophenyl)guanidine (30 gm) at room temperature. A solution of sodium (17.2 gm) in ethanol (450 ml) was added to the above reaction mass. The contents were heated to reflux and maintained for 12 hours. Distilled off the solvent completely under vacuum and then added water (500 ml). The reaction mass was stirred for 30 minutes and filtered. The solid obtained was dried to obtain 40 gm of 4-(4,6-dihydroxypyrimidine-2-yl-amino)benzonitrile.

1. temperatureThe contents were heated
2. temperatureto reflux
3. temperaturemaintained for 12 hours
4. distillationDistilled off the solvent completely under vacuum
5. filtrationfiltered
6. customThe solid obtained
7. customwas dried