Trifluoroacetic acid → HCID 67339494, compound

HRID 1909136Notes

Reaction equation

HRID 1909136 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([CH:19]=[C:20]([CH:22]([OH:27])[C:23]([F:26])([F:25])[F:24])[N:21]=1)[C:12]([O:14]C(C)(C)C)=[O:13].FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([CH:19]=[C:20]([CH:22]([OH:27])[C:23]([F:26])([F:24])[F:25])[N:21]=1)[C:12]([OH:14])=[O:13]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 67338922HCID 67338922, compound

Product 1

HCID 67339494HCID 67339494, compoundYield 89.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2-(2,4-difluorophenyl)-6-(2,2,2-trifluoro-1-hydroxyethyl)isonicotinate (0.56 g, 1.44 mmol) in dichloromethane (3 mL) was added trifluoroacetic acid (3 mL). The mixture was stirred at ambient temperature. After 18 h, additional trifluoroacetic acid (1 mL) was added and the mixture was stirred at ambient for 1 h. The mixture was concentrated to dryness to give the title compound (0.43 g). MS 334.2 (M+1).

Workup

  1. stirringthe mixture was stirred at ambient for 1 h
  2. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-093579755ef249d69f88a0159404e71c
Source dataset
uspto-grants-2013_12
Patent number
US08598209B2

Reaction notes

Loading…