Hydrochloric Acid → HCID 67337799, compound

HRID 1909143Notes

Reaction equation

HRID 1909143 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([O:16]C)=[O:15])[CH:11]=[C:10]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)[N:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C1COCC1.O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=[O:15])[CH:11]=[C:10]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)[N:9]=2)=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67337889HCID 67337889, compound

Product 1

HCID 67337799HCID 67337799, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 2,6-bis(4-methylphenyl)pyrimidine-4-carboxylate (0.31 g, 0.98 mmol) in THF (10 mL) and water (10 mL) were added sodium hydroxide (1.0 M in water; 2.05 mL, 2.05 mmol). The mixture was stirred at ambient temperature. After 18 h, HCl (1.0 M in water) was added and the mixture was extracted with dichloromethane (3×). The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated. MS 305.1 (M+1).

Workup

  1. extractionthe mixture was extracted with dichloromethane (3×)
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-d2a2b00a25c947cc9c9c86c523cf89c1
Source dataset
uspto-grants-2013_12
Patent number
US08598209B2

Reaction notes

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