反应详情

In a 50 mL flask, 4-Benzo[1,3]dioxol-4-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (1.22 g, 4.02 mmol was combined with dichloromethane (20 ml) to give a colorless solution. Hydrochloric acid solution, 4M in dioxane (10.1 ml, 40.2 mmol) was added and the reaction mixture was stirred for 4 hours at room temperature. 15 ml of diisoproylether were added and the mixture was stirred for 5 min at 0° C. The precipitate was collected by filtration, washed with 2 ml of diisopropylether and dried to yield the title compound as a white solid (0.820 grs, 85%). MS (ISP) m/z=204.2[(M+H)+].

1. customto give a colorless solution
2. stirringthe mixture was stirred for 5 min at 0° C
3. filtrationThe precipitate was collected by filtration
4. washwashed with 2 ml of diisopropylether
5. customdried