Hydrochloric Acid → 6-(2-Hydroxypropan-2-yl)-3,4'-bipyridine-2'-carboxylic acid hydrochloride salt

HRID 1909462Notes

Reaction equation

HRID 1909462 reaction equation
[OH:1][C:2]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]([O:19]C(C)C)=[O:18])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[ClH:23]>>[ClH:23].[OH:1][C:2]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]([OH:19])=[O:18])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66848234Isopropyl 6-(2-hydroxypropan-2-yl)-3,4'-bipyridine-2'-carboxylate

Product 1

HCID 668482386-(2-Hydroxypropan-2-yl)-3,4'-bipyridine-2'-carboxylic acid hydrochloride saltYield 87%

Procedure

A solution of isopropyl 6-(2-hydroxypropan-2-yl)-3,4′-bipyridine-2′-carboxylate (140 mg, 0.47 mmol) in 1 M hydrochloric acid (2 mL) was heated at 100° C. overnight. The solvent was removed under reduced pressure to give 6-(2-hydroxypropan-2-yl)-3,4′-bipyridine-2′-carboxylic acid hydrochloride salt as a white powder (106 mg, 87%). 259.1 (M+1).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-97977b2b59ee4a82b6e4ed0c9a978296
Source dataset
uspto-grants-2013_12
Patent number
US08598360B2

Reaction notes

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