Triphenylphosphine → HCID 86643715, compound

HRID 1909544Notes

Reaction equation

HRID 1909544 reaction equation
[Cl:1][CH2:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[CH:6]=[C:5]([F:14])[CH:4]=1.[C:15]1([P:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[Cl-:1].[F:14][C:5]1[CH:4]=[C:3]([CH2:2][P+:21]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 58566560HCID 58566560, compound

Product 1

HCID 86643715HCID 86643715, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-(chloromethyl)-5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran (647) (1 g, 4.66 mmol), triphenyl phosphine (1.22 g, 4.66 mmol) and toluene (46 mL) were heated at reflux for 48 hours. The reaction was filtered and the solid was washed with diethyl ether to provide ((5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methyl)triphenyl phosphonium chloride (648).

Workup

  1. temperatureat reflux for 48 hours
  2. filtrationThe reaction was filtered
  3. washthe solid was washed with diethyl ether

Sources & evidence

ORD record
ord-1aab53c4d1614b568ae23fa3d5a48c2d
Source dataset
uspto-grants-2013_12
Patent number
US08598374B2

Reaction notes

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