Tetrahydrofuran → 103854-63-3

HRID 1909777Notes

Reaction equation

HRID 1909777 reaction equation
C([O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.C1COCC1>[Pd].CCO>[N:17]1[CH:16]=[CH:15][C:14]([O:13][C:12]2[CH:20]=[CH:21][C:9]([OH:8])=[CH:10][CH:11]=2)=[CH:19][CH:18]=1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 68996846HCID 68996846, compound

Product 1

HCID 18794474103854-63-3Yield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The same procedure from Example 143, step 2 was followed using the product from step 1 (306 mg, 0.905 mmol), THF (3 ml), EtOH (9 ml), 10% Pd/C (300 mg, 0.0905 mmol) to give the title compound (160 mg, 95%).

Sources & evidence

ORD record
ord-9ccf9612ac404c6f9d99d1fc5a3a5917
Source dataset
uspto-grants-2013_12
Patent number
US08598359B2

Reaction notes

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