Potassium Carbonate → HCID 59752954, compound

HRID 1909794Notes

Reaction equation

HRID 1909794 reaction equation
[C:1]1([C:7]2[CH:11]=[CH:10][NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+]>C(C(C)=O)C>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][N:9]2[CH:10]=[CH:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:8]2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 699934-Methyloxybenzyl chlorideHCID 178420101HCID 178420101, compound

Product 1

HCID 59752954HCID 59752954, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 3-phenyl-1H-pyrazole (1.35 g, 9.36 mmol), 4-methoxybenzyl chloride (1.5 g, 9.7 mmol) and K2CO3 (3.3 g, 24.2 mmol) in methyl ethyl ketone was refluxed for 24 h. The salts were filtered off, and the solvent was removed in vacuo. The residue was purified by a column chromatography on silica gel to yield the title compound (2.2 g, 89%).

Workup

  1. temperaturewas refluxed for 24 h
  2. filtrationThe salts were filtered off
  3. customthe solvent was removed in vacuo
  4. customThe residue was purified by a column chromatography on silica gel

Sources & evidence

ORD record
ord-69c940d0c7094c91951e5ee17b016b82
Source dataset
uspto-grants-2013_12
Patent number
US08598359B2

Reaction notes

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